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FOXL2 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC-P - FOXL2 Antibody (C-Terminus) ALS17229
    Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • WB - FOXL2 Antibody (C-Terminus) ALS17229
    Antibody staining (1.5 ug/ml) of Human Ovary extracts (RIPA buffer, 30 ug total protein per lane).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P58012
Other Accession 668
Reactivity Human, Mouse, Rat, Rabbit, Monkey, Pig, Bovine
Host Goat
Clonality Polyclonal
Calculated MW 38772 Da
Dilution ELISA (1:16000), IHC-P (5 µg/ml), WB (1:16000),
Additional Information
Gene ID 668
Other Names FOXL2, BPES, BPES1, Forkhead box L2, Forkhead box protein L2, PFRK, PINTO, POF3
Target/Specificity Human FOXL2.
Reconstitution & Storage Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsFOXL2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXL2
Function Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:19744555}
Tissue Location In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary
Volume 50 µl
Citations (0)
citation

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Background

Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.

References

Crisponi L.,et al.Nat. Genet. 27:159-166(2001).
Xu Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Lee K.,et al.Biochem. Biophys. Res. Commun. 336:876-881(2005).
Kuo F.T.,et al.Cell. Signal. 21:1935-1944(2009).
Benayoun B.A.,et al.Hum. Mol. Genet. 18:632-644(2009).

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Discontinued
Cat# ALS17229
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