COPS2 / TRIP15 / ALIEN Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
---|---|
Primary Accession | P61201 |
Other Accession | 9318 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 51597 Da |
Dilution | IF (1:50 - 1:100), IHC-P (5 µg/ml), WB (1:500 - 1:2000), |
Gene ID | 9318 |
---|---|
Other Names | COPS2, Alien homolog, ALIEN, SGN2, TRIP15, TR-interacting protein 15, Signalosome subunit 2, TRIP-15 |
Target/Specificity | Human COPS2 / TRIP15 / ALIEN. |
Reconstitution & Storage | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles. |
Precautions | COPS2 / TRIP15 / ALIEN Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | COPS2 |
---|---|
Synonyms | CSN2, TRIP15 |
Function | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. |
Cellular Location | Cytoplasm. Nucleus |
Volume | 50 µl |
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Background
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
References
Dumdey R.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Peng Y.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Lee J.W.,et al.Mol. Endocrinol. 9:243-254(1995).
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