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Anti-HAMP / Hepcidin Antibody

Rabbit Anti Human Polyclonal Antibody

     
  • IHC-P - Anti-HAMP / Hepcidin Antibody  ALS17322
    Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P81172
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 9408 Da
Dilution IHC-P (1:200), WB (1:500 - 1:2000)
Additional Information
Gene ID 57817
Alias Symbol HAMP
Other Names HAMP, Hepcidin antimicrobial peptide, LEAP-1, LEAP1, HEPC, Hepcidin, HFE2B, PLTR, Putative liver tumor regressor
Target/Specificity Human HAMP / Hepcidin
Reconstitution & Storage PBS, 0.1% sodium azide, 50% glycerol Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsAnti-HAMP / Hepcidin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HAMP (HGNC:15598)
Synonyms HEPC, LEAP1
Function Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342). Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).
Cellular Location Secreted.
Tissue Location Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine and blood (PubMed:11034317). Expressed by hepatocytes (PubMed:15124018).
Research Areas
Citations (0)
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Discontinued
Cat# ALS17322
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