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Anti-BAFF Antibody (aa83-285, clone Buffy-1)
Rat Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC, FC |
|---|---|
| Primary Accession | Q9Y275 |
| Predicted | Human |
| Host | Rat |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone Names | Buffy-1 |
| Calculated MW | 31223 Da |
| Dilution | Flo, ICC, IHC-P (10 µg/ml), WB |
| Gene ID | 10673 |
|---|---|
| Alias Symbol | TNFSF13B |
| Other Names | TNFSF13B, B-cell-activating factor, BAFF, ApoL related ligand TALL-1, B-lymphocyte stimulator, CD257, BLYS, Delta4 BAFF, Delta BAFF, TALL-1, TALL1, ZTNF4, THANK, B lymphocyte stimulator, CD257 antigen, TNFSF20 |
| Target/Specificity | Recognizes membrane-bound human BAFF. Detects endogenous protein by FC. |
| Reconstitution & Storage | Gel filtration |
| Precautions | Anti-BAFF Antibody (aa83-285, clone Buffy-1) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNFSF13B |
|---|---|
| Synonyms | BAFF, BLYS, TALL1, TNFSF20, ZTNF4 |
| Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T- cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B- cells and the B-cell response. |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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