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Anti-ATP2A1 / SERCA1 Antibody (clone 4B8)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | O14983 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG3,k |
| Clone Names | 4B8 |
| Calculated MW | 110252 Da |
| Dilution | IHC-P (5 µg/ml), WB |
| Gene ID | 487 |
|---|---|
| Alias Symbol | ATP2A1 |
| Other Names | ATP2A1, SERCA1, ATP2A, Calcium pump 1, SR Ca(2+)-ATPase 1 |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-ATP2A1 / SERCA1 Antibody (clone 4B8) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATP2A1 (HGNC:811) |
|---|---|
| Function | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04191}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04191} |
| Tissue Location | Skeletal muscle, fast twitch muscle (type II) fibers. |
Research Areas
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