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Anti-CSE1L Antibody (clone 2F4)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | P55060 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone Names | 2F4 |
| Calculated MW | 110417 Da |
| Dilution | ELISA, IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500 - 1:1000) |
| Gene ID | 1434 |
|---|---|
| Alias Symbol | CSE1L |
| Other Names | CSE1L, CAS, CSE1, Exp2, Importin-alpha re-exporter, Exportin-2, XPO2 |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-CSE1L Antibody (clone 2F4) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CSE1L |
|---|---|
| Synonyms | CAS {ECO:0000303|PubMed:7479798}, XPO2 |
| Function | Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Cellular Location | Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. |
| Tissue Location | Detected in brain, placenta, ovary, testis and trachea (at protein level) (PubMed:10331944). Widely expressed (PubMed:10331944). Highly expressed in testis and in proliferating cells (PubMed:7479798, PubMed:10331944). |
Research Areas
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