Anti-TNFRSF1B / TNFR2 Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E, Neut |
---|---|
Primary Accession | P20333 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 48291 Da |
Dilution | ELISA (0.5 - 2 µg/ml), IHC-P (5 µg/ml), Neut (15 - 20 µg/ml), WB (0.1 - 0.2 µg/ml) |
Gene ID | 7133 |
---|---|
Alias Symbol | TNFRSF1B |
Other Names | TNFRSF1B, CD120b antigen, CD120b, Etanercept, p75 TNF receptor, Soluble TNFR1B variant 1, TNFBR, Tumor necrosis factor receptor, TNF-R-II, TNF-R75, TNFR2, p75TNFR, p80 TNF-alpha receptor, TBPII, TNF-R2, TNFR80, TNF-RII, TNFR-II, TNFR1B |
Target/Specificity | Human sTNF Receptor-II |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-TNFRSF1B / TNFR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TNFRSF1B |
---|---|
Synonyms | TNFBR, TNFR2 |
Function | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. |
Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Tumor necrosis factor-binding protein 2]: Secreted |
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