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Anti-MAP3K11 / MLK3 Antibody (clone 3D11)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-F, E |
|---|---|
| Primary Accession | Q16584 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a,k |
| Clone Names | 3D11 |
| Calculated MW | 92688 Da |
| Dilution | ELISA, IHC-Fr (1:50), WB |
| Gene ID | 4296 |
|---|---|
| Alias Symbol | MAP3K11 |
| Other Names | MAP3K11, Mixed lineage kinase 3, MLK3, Protein-tyrosine kinase PTK1, PTK1, SPRK, MLK-3, MEKK11 |
| Target/Specificity | Human MAP3K11 |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-MAP3K11 / MLK3 Antibody (clone 3D11) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAP3K11 (HGNC:6850) |
|---|---|
| Function | Activates the JUN N-terminal pathway. Required for serum- stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen- stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell cycle dependent |
| Tissue Location | Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain. |
Research Areas
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Application Protocols
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$ 533.50
Cat# ALS17851
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