Anti-CYP8B1 Antibody (aa357-406)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q9UNU6 |
Predicted | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 58068 Da |
Dilution | ELISA, IHC-P (1:50), WB |
Gene ID | 1582 |
---|---|
Alias Symbol | CYP8B1 |
Other Names | CYP8B1, CYP12, Cytochrome P450 8B1, CP8B, Sterol 12-alpha-hydroxylase, Sterol 12alpha-hydroxylase, CYPVIIIB1 |
Target/Specificity | Cytochrome P450 8B1 antibody detects endogenous levels of Cytochrome P450 8B1. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-CYP8B1 Antibody (aa357-406) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CYP8B1 {ECO:0000303|PubMed:10051404, ECO:0000312|HGNC:HGNC:2653} |
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Function | A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis. Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4- cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis (PubMed:10051404). Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase) (By similarity). |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O02766}; Single-pass membrane protein. Microsome membrane {ECO:0000250|UniProtKB:O02766}; Single-pass membrane protein |
Tissue Location | Liver.. |
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