Anti-BCL11A Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q9H165 |
Predicted | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 91197 Da |
Dilution | IHC-P (1:200), WB (1:500 - 1:2000) |
Gene ID | 53335 |
---|---|
Alias Symbol | BCL11A |
Other Names | BCL11A, B-cell CLL/lymphoma 11A, BCL11A-L, BCL11A-XL, BCL11a-M, B-cell lymphoma/leukemia 11A, BCL-11A, BCL11A-S, CTIP1, COUP-TF-interacting protein 1, HBFQTL5, EVI-9, KIAA1809, ZNF856, C2H2-type zinc finger protein, EVI9, Zinc finger protein 856 |
Target/Specificity | Human BCL11A |
Reconstitution & Storage | Affinity purified |
Precautions | Anti-BCL11A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BCL11A |
---|---|
Synonyms | CTIP1, EVI9, KIAA1809, ZNF856 |
Function | Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). |
Cellular Location | Cytoplasm. Nucleus. Chromosome. Note=Associates with the nuclear body Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity) [Isoform 2]: Cytoplasm. Nucleus Note=Predominantly localized in the nucleus in nuclear paraspeckles |
Tissue Location | Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development. |
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