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Anti-BCL11A Antibody

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9H165
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 91197 Da
Dilution IHC-P (1:200), WB (1:500 - 1:2000)
Additional Information
Gene ID 53335
Alias Symbol BCL11A
Other Names BCL11A, B-cell CLL/lymphoma 11A, BCL11A-L, BCL11A-XL, BCL11a-M, B-cell lymphoma/leukemia 11A, BCL-11A, BCL11A-S, CTIP1, COUP-TF-interacting protein 1, HBFQTL5, EVI-9, KIAA1809, ZNF856, C2H2-type zinc finger protein, EVI9, Zinc finger protein 856
Target/Specificity Human BCL11A
Reconstitution & Storage Affinity purified
PrecautionsAnti-BCL11A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL11A
Synonyms CTIP1, EVI9, KIAA1809, ZNF856
Function Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity).
Cellular Location Cytoplasm. Nucleus. Chromosome. Note=Associates with the nuclear body Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity) [Isoform 2]: Cytoplasm. Nucleus Note=Predominantly localized in the nucleus in nuclear paraspeckles
Tissue Location Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development.
Research Areas
Citations (0)
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Discontinued
Cat# ALS18168
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