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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-SLC22A5 / OCTN2 Antibody
Anti-SLC22A5 / OCTN2 Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | O76082 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 62752 Da |
| Dilution | IF (1:50 - 1:200), IHC-P (1:100), WB (1:500 - 1:2000) |
| Gene ID | 6584 |
|---|---|
| Alias Symbol | SLC22A5 |
| Other Names | SLC22A5, CDSP, OCTN2VT, OCTN2, UST2 |
| Target/Specificity | Human SLC22A5 / OCTN2 |
| Reconstitution & Storage | Affinity purified |
| Precautions | Anti-SLC22A5 / OCTN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC22A5 (HGNC:10969) |
|---|---|
| Function | Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine (PubMed:10454528, PubMed:10525100, PubMed:10966938, PubMed:17509700, PubMed:20722056, PubMed:33124720). Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 11.3 (PubMed:10454528, PubMed:10525100, PubMed:10966938). In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from Bacillus Subtilis wich induces cytoprotective heat shock proteins contributing to intestinal homeostasis (PubMed:18005709). May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basal cell membrane; Multi-pass membrane protein. Note=In intestinal cells, apical expression is induced by TNF. Localized to the basal membrane of Sertoli cells (PubMed:35307651). |
| Tissue Location | Strongly expressed in kidney, skeletal muscle, heart and placenta (PubMed:10454528). Primarily expressed by surface epithelial cells of the colon (at protein level) (PubMed:18005709) Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells (PubMed:10454528). In testis, localized to Sertoli cell basal membranes, peritubular myoid cells and Leydig cells (PubMed:35307651) |
Research Areas
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