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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-ABCC10 Antibody (aa835-884)
Anti-ABCC10 Antibody (aa835-884)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q5T3U5 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 161629 Da |
| Dilution | ELISA, IHC-P (1:50), WB |
| Gene ID | 89845 |
|---|---|
| Alias Symbol | ABCC10 |
| Other Names | ABCC10, EST182763, Multidrug resistance protein 7, MRP7, SIMRP7 |
| Target/Specificity | MRP7 Antibody detects endogenous levels of total MRP7 protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-ABCC10 Antibody (aa835-884) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ABCC10 |
|---|---|
| Synonyms | MRP7, SIMRP7 |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o- glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:12527806, PubMed:15256465). May contribute to regulate the transport of organic compounds in testes across the blood-testis- barrier (Probable). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel (PubMed:15256465, PubMed:23087055). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP (PubMed:12527806). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12566991, ECO:0000269|PubMed:15256465}. Basolateral cell membrane; Multi-pass membrane protein. Basal cell membrane; Multi-pass membrane protein. Note=Localized to the basal membrane of Sertoli cells. |
| Tissue Location | In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells, moderately in the adluminal compartment of the seminiferous tubules, and in vascular endothelial cells. [Isoform 2]: Widely expressed. |
Research Areas
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$ 555.50
Cat# ALS18362
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