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FSHB/FSH Antibody (Center)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P01225 |
| Other Accession | NP_000501.1, NP_001018090.1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG3 |
| Clone/Animal Names | 365CT24.1.1 |
| Calculated MW | 14700 Da |
| Antigen Region | 36-64 aa |
| Gene ID | 2488 |
|---|---|
| Other Names | Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain, FSHB |
| Target/Specificity | This FSHB/FSH antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the Central region of human FSHB/FSH. |
| Dilution | WB~~1:150~1500 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FSHB/FSH Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FSHB |
|---|---|
| Function | Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432). |
| Cellular Location | Secreted. Note=Efficient secretion requires dimerization with CGA |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.
References
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Corpuz, P.S., et al. Mol. Endocrinol. 24(5):1037-1051(2010)
Grigorova, M., et al. J. Clin. Endocrinol. Metab. 95(1):100-108(2010)
Ahn, J., et al. Hum. Mol. Genet. 18(19):3749-3757(2009)
Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)
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