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ACHE Antibody (C-term)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P22303 |
| Other Accession | Q29499, P23795 |
| Reactivity | Human, Mouse, Rat, African Green Monkey |
| Predicted | Bovine, Rabbit |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone/Animal Names | 684CT8.3.4 |
| Calculated MW | 67796 Da |
| Antigen Region | 587-611 aa |
| Gene ID | 43 |
|---|---|
| Other Names | Acetylcholinesterase, AChE, ACHE |
| Target/Specificity | This ACHE antibody is generated from mouse immunized with a KLH conjugated synthetic peptide between 587-611 amino acids from the C-terminal region of human ACHE. |
| Dilution | WB~~1:2000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ACHE Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ACHE (HGNC:108) |
|---|---|
| Function | Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis. |
| Cellular Location | Synapse. Secreted. Cell membrane; Peripheral membrane protein [Isoform H]: Cell membrane; Lipid- anchor, GPI-anchor; Extracellular side |
| Tissue Location | Isoform H is highly expressed in erythrocytes. |
Provided below are standard protocols that you may find useful for product applications.
Background
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
References
Soreq H., et al. Proc. Natl. Acad. Sci. U.S.A. 87:9688-9692(1990).
Karpel R., et al. Exp. Cell Res. 210:268-277(1994).
Yang L., et al. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
Ota T., et al. Nat. Genet. 36:40-45(2004).
Totoki Y., et al. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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