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PDXK Antibody (N-term)
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O00764 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,k |
| Clone/Animal Names | 1007CT2.1.1 |
| Calculated MW | 35102 Da |
| Gene ID | 8566 |
|---|---|
| Other Names | Pyridoxal kinase, 2.7.1.35, Pyridoxine kinase, PDXK, C21orf124, C21orf97, PKH, PNK |
| Target/Specificity | This PDXK antibody is generated from a mouse immunized with a recombinant protein between 1-312 amino acids from human PDXK. |
| Dilution | WB~~1:4000 IHC-P~~1:25 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PDXK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDXK (HGNC:8819) |
|---|---|
| Function | Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (PubMed:9099727, PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503) (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions. |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Ubiquitous (PubMed:9099727, PubMed:31187503). Highly expressed in testis (PubMed:9099727) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
References
Hanna M.C.,et al.J. Biol. Chem. 272:10756-10760(1997).
Fang X.,et al.Asian J. Androl. 6:83-91(2004).
Hattori M.,et al.Nature 405:311-319(2000).
Lee H.-S.,et al.Mol. Cells 10:452-459(2000).
Daub H.,et al.Mol. Cell 31:438-448(2008).
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