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Mouse Monoclonal Antibody to TTF1
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, ICC, E |
|---|---|
| Primary Accession | Q15361 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2F4D8 |
| Isotype | Mouse IgG1 |
| Calculated MW | 103kDa |
| Description | This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression.; |
| Immunogen | Purified recombinant fragment of human TTF1 (AA: 1-150) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 IHC: 1/200 - 1/1000 ICC: 1/200 - 1/1000 FCM: 1/200 - 1/400 |
| Gene ID | 7270 |
|---|---|
| Other Names | TTF-1; TTF-I |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to TTF1 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TTF1 |
|---|---|
| Function | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q62187}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q62187}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q62187}. Note=May be localized to the nucleolus in an NPM1/B23-dependent manner. May be displaced from the nucleolus into the nucleoplasm in an CDKN2A/ARF-dependent manner. May shuttle back and forth from nucleoplasm to nucleolus {ECO:0000250|UniProtKB:Q62187} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Tumour Biol. 2015 Sep;36(10):8085-92. ; 2.Chest. 2013 Oct;144(4):1199-206.;
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$ 385.00
Cat# AO2366a
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