Mouse Monoclonal Antibody to ZFP91
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, FC, ICC, E |
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Primary Accession | Q96JP5 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 7G11H2 |
Isotype | Mouse IgG1 |
Calculated MW | 63.4kDa |
Description | The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2.; |
Immunogen | Purified recombinant fragment of human ZFP91 (AA: 162-304) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 IHC: 1/200 - 1/1000 ICC: 1/100 - 1/500 FCM: 1/200 - 1/400 |
Gene ID | 80829 |
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Other Names | PZF; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Monoclonal Antibody to ZFP91 is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZFP91 |
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Synonyms | ZNF757 |
Function | Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF- kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. |
Cellular Location | Nucleus. |
Tissue Location | Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific |
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Provided below are standard protocols that you may find useful for product applications.
References
1.Pathol Oncol Res. 2014 Apr;20(2):453-9. ; 2.Biochem Biophys Res Commun. 2010 Oct 1;400(4):581-6.;
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