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CHRNA10

Purified Mouse Monoclonal Antibody

     
  • E - CHRNA10 AO2620a
    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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  • WB - CHRNA10 AO2620a
    Figure 2:Western blot analysis using CHRNA10 mAb against human CHRNA10 (AA: extra 25-237) recombinant protein. (Expected MW is 50 kDa)
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  • WB - CHRNA10 AO2620a
    Figure 3:Western blot analysis using CHRNA10 mAb against HEK293 (1) and CHRNA10 (AA: extra 25-237)-hIgGFc transfected HEK293 (2) cell lysate.
    detail
  • FCM - CHRNA10 AO2620a
    Figure 4:Flow cytometric analysis of Hela cells using CHRNA10 mouse mAb (green) and negative control (red).
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, ICC, E
Primary Accession Q9GZZ6
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4E2D1
Isotype Mouse IgG2a
Calculated MW 49.7kDa
Immunogen Purified recombinant fragment of human CHRNA10 (AA: extra 25-237) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 57053
Dilution E~~ 1/10000
WB~~ 1/500 - 1/2000
FCM~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCHRNA10 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHRNA10
Synonyms NACHRA10
Function Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
Cellular Location Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes
Research Areas
Citations (0)
citation

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References

1.J Neurochem. 2012 Sep;122(6):1137-44.2.Genes Brain Behav. 2010 Oct;9(7):741-50.

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$ 385.00
Cat# AO2620a
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