CCNY Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
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Primary Accession | Q8ND76 |
Other Accession | Q8BGU5, NP_659449.3, NP_859049.2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 39337 Da |
Antigen Region | 140-169 aa |
Gene ID | 219771 |
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Other Names | Cyclin-Y, Cyc-Y, Cyclin box protein 1, Cyclin fold protein 1, cyclin-X, CCNY, C10orf9, CBCP1, CFP1 |
Target/Specificity | This CCNY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-169 amino acids from the Central region of human CCNY. |
Dilution | WB~~1:1000 IHC-P~~1:100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CCNY Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CCNY |
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Synonyms | C10orf9, CBCP1, CFP1 |
Function | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. |
Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side |
Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).
References
Wang, K., et al. Hum. Mol. Genet. 19(10):2059-2067(2010)
Xu, Y., et al. Oncol. Res. 18(8):359-364(2010)
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Henckaerts, L., et al. Clin. Gastroenterol. Hepatol. 7(9):972-980(2009)
Jiang, M., et al. FEBS Lett. 583(13):2171-2178(2009)
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