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TdT Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TdT Antibody (C-term) AP11561b
    TdT Antibody (C-term) (Cat. #AP11561b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TdT antibody detected the TdT protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P04053
Other Accession P09838, NP_001017520.1, NP_004079.3
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 58536 Da
Antigen Region 438-467 aa
Additional Information
Gene ID 1791
Other Names DNA nucleotidylexotransferase, Terminal addition enzyme, Terminal deoxynucleotidyltransferase, Terminal transferase, DNTT, TDT
Target/Specificity This TdT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-467 amino acids from the C-terminal region of human TdT.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTdT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DNTT
Synonyms TDT {ECO:0000303|PubMed:11473582}
Function Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
Cellular Location Nucleus.
Research Areas
Citations (0)
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Background

This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

References

Kubota, T., et al. Genes Cells 12(8):941-959(2007)
O'Malley, D.P., et al. Haematologica 91(8):1139-1140(2006)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Thai, T.H., et al. J. Immunol. 173(6):4009-4019(2004)
Liu, L., et al. Am. J. Clin. Pathol. 121(6):810-815(2004)

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$ 365.00
$ 140.00
Cat# AP11561b
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