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POSTN Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF, WB, FC, E |
|---|---|
| Primary Accession | Q15063 |
| Other Accession | NP_006466 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 93314 Da |
| Antigen Region | 687-716 aa |
| Gene ID | 10631 |
|---|---|
| Other Names | Periostin, PN, Osteoblast-specific factor 2, OSF-2, POSTN, OSF2 |
| Target/Specificity | This POSTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 687-716 amino acids from the C-terminal region of human POSTN. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:100 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | POSTN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | POSTN |
|---|---|
| Synonyms | OSF2 |
| Function | Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). |
| Cellular Location | Golgi apparatus {ECO:0000250|UniProtKB:Q62009}. Secreted Secreted, extracellular space, extracellular matrix Note=Colocalizes with BMP1 in the Golgi {ECO:0000250|UniProtKB:Q62009} |
| Tissue Location | Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Expressed in the kidney (PubMed:21763681). Expressed in the lung (PubMed:22079858). Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor Overexpressed in breast cancers. |
Provided below are standard protocols that you may find useful for product applications.
Background
POSTN binds to heparin. It induces cell attachment and spreading and plays a role in cell adhesion and may play a role in extracellular matrix mineralization.
References
Zhu, M., et al. Gynecol. Oncol. 119(2):337-344(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Takada, M., et al. Biochem. Biophys. Res. Commun. 399(2):221-226(2010)
Sidhu, S.S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14170-14175(2010)
Tischler, V., et al. BMC Cancer 10, 273 (2010) :
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