CPB1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, FC, E |
---|---|
Primary Accession | P15086 |
Other Accession | NP_001862.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 47368 Da |
Antigen Region | 9-37 aa |
Gene ID | 1360 |
---|---|
Other Names | Carboxypeptidase B, Pancreas-specific protein, PASP, CPB1, CPB, PCPB |
Target/Specificity | This CPB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human CPB1. |
Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CPB1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CPB1 |
---|---|
Synonyms | CPB, PCPB |
Cellular Location | Secreted {ECO:0000250|UniProtKB:P00732}. Zymogen granule lumen {ECO:0000250|UniProtKB:P55261} |
Tissue Location | Pancreas.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Pantoja-Uceda, D., et al. Biochemistry 47(27):7066-7078(2008)
Guimaraes, A.H., et al. Arterioscler. Thromb. Vasc. Biol. 27(10):2157-2162(2007)
Barbosa Pereira, P.J., et al. J. Mol. Biol. 321(3):537-547(2002)
Aloy, P., et al. Biol. Chem. 379(2):149-155(1998)
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