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WDR34 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - WDR34 Antibody (Center) AP12421C
    WDR34 Antibody (Center) (Cat. #AP12421c) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the WDR34 antibody detected the WDR34 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q96EX3
Other Accession NP_443076.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 57801 Da
Antigen Region 305-334 aa
Additional Information
Gene ID 89891
Other Names WD repeat-containing protein 34, WDR34
Target/Specificity This WDR34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-334 amino acids from the Central region of human WDR34.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsWDR34 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DYNC2I2 (HGNC:28296)
Synonyms WDR34
Function Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:25205765, PubMed:29742051). DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis (PubMed:30649997, PubMed:29742051, PubMed:30320547). Required also to maintain a functional transition zone (PubMed:30320547).
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cell projection, filopodium {ECO:0000250|UniProtKB:Q5U4F6}. Note=Concentrates around the centrioles and basal bodies also showing axonemal staining {ECO:0000250|UniProtKB:Q5U4F6}
Tissue Location Expressed in several cell lines (at protein level).
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

References

Gao, D., et al. Cell. Mol. Life Sci. 66(15):2573-2584(2009)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)

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$ 182.50
$ 70.00
Cat# AP12421C
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