METTL11B Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q5VVY1 |
Other Accession | D3ZVR1, B2RXM4, NP_001129579.1 |
Reactivity | Mouse |
Predicted | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 32400 Da |
Antigen Region | 14-42 aa |
Gene ID | 149281 |
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Other Names | Alpha N-terminal protein methyltransferase 1B, Methyltransferase-like protein 11B, X-Pro-Lys N-terminal protein methyltransferase 1B, NTM1B, METTL11B, C1orf184, NRMT2 |
Target/Specificity | This METTL11B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human METTL11B. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | METTL11B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NTMT2 (HGNC:31932) |
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Function | Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif (PubMed:24090352, PubMed:30417120). Predominantly functions as a mono- methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro) (PubMed:30417120). May activate NTMT1 by priming its substrates for trimethylation (PubMed:24090352). |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
METTL11B is alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di-or tri-methylation of exposed alpha-amino group of Ala, Pro or Ser residue in the [Ala/Pro/Ser]-Pro-Lys motif (By similarity).
References
Gregory, S.G., et al. Nature 441(7091):315-321(2006)
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