PNKD Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q8N490 |
Other Accession | Q69ZP3, A7YY46, NP_001070867.1, NP_056303.3 |
Reactivity | Mouse |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42876 Da |
Antigen Region | 42-70 aa |
Gene ID | 25953 |
---|---|
Other Names | Probable hydrolase PNKD, 3---, Myofibrillogenesis regulator 1, MR-1, Paroxysmal nonkinesiogenic dyskinesia protein, Trans-activated by hepatitis C virus core protein 2, PNKD, KIAA1184, MR1, TAHCCP2 |
Target/Specificity | This PNKD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human PNKD. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PNKD Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PNKD |
---|---|
Synonyms | KIAA1184, MR1, TAHCCP2 |
Function | Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. |
Cellular Location | [Isoform 1]: Membrane; Peripheral membrane protein [Isoform 3]: Mitochondrion. |
Tissue Location | Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants.
References
Yang, J., et al. Neuron 66(6):871-883(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Ghezzi, D., et al. Hum. Mol. Genet. 18(6):1058-1064(2009)
Friedman, A., et al. Eur. Neurol. 61(1):39-41(2009)
Ren, K., et al. J. Biol. Chem. 283(51):35598-35605(2008)
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