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TTLL4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q14679 |
| Other Accession | NP_055455.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 133378 Da |
| Antigen Region | 464-493 aa |
| Gene ID | 9654 |
|---|---|
| Other Names | Tubulin polyglutamylase TTLL4, 6---, Tubulin--tyrosine ligase-like protein 4, TTLL4, KIAA0173 |
| Target/Specificity | This TTLL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-493 amino acids from the Central region of human TTLL4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TTLL4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TTLL4 (HGNC:28976) |
|---|---|
| Synonyms | KIAA0173 |
| Function | Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side- chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q80UG8}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80UG8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80UG8} Note=Located in cilia. In some cells, also found in basal bodies {ECO:0000250|UniProtKB:Q80UG8} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TTLL4 is polyglutamylase which preferentially modifies beta-tubulin and nucleosome assembly proteins NAP1 and NAP2. It is involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity).
References
Trichet, V., et al. Gene 257(1):109-117(2000)
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