KERA Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, IHC-P-Leica, E |
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Primary Accession | O60938 |
Other Accession | NP_008966.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 40509 Da |
Antigen Region | 228-257 aa |
Gene ID | 11081 |
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Other Names | Keratocan, KTN, Keratan sulfate proteoglycan keratocan, KERA, SLRR2B |
Target/Specificity | This KERA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-257 amino acids from the C-terminal region of human KERA. |
Dilution | WB~~1:1000 IHC-P-Leica~~1:500 FC~~1:25 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KERA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KERA |
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Synonyms | SLRR2B |
Function | May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. |
Cellular Location | Secreted, extracellular space, extracellular matrix |
Tissue Location | Cornea (at protein level) (PubMed:10802664, PubMed:11683372). Increased expression in the stroma of keratoconus corneas (PubMed:11683372). Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen (PubMed:10802664). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).
References
Aldave, A.J., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4006-4012(2010)
Dimasi, D.P., et al. Mol. Vis. 16, 562-569 (2010) :
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Melrose, J., et al. Arthritis Res. Ther. 10 (4), R79 (2008) :
Liskova, P., et al. Mol. Vis. 13, 1339-1347 (2007) :
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