ONECUT1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9UBC0 |
Other Accession | P70512, O08755, NP_004489.1 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 51023 Da |
Antigen Region | 356-385 aa |
Gene ID | 3175 |
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Other Names | Hepatocyte nuclear factor 6, HNF-6, One cut domain family member 1, One cut homeobox 1, ONECUT1, HNF6, HNF6A |
Target/Specificity | This ONECUT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 356-385 amino acids from the C-terminal region of human ONECUT1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ONECUT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ONECUT1 |
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Synonyms | HNF6, HNF6A |
Function | Transcriptional activator. Binds the consensus sequence 5'- DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. |
Cellular Location | Nucleus. |
Tissue Location | Highly expressed in liver; lower expression in testis and skin |
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Provided below are standard protocols that you may find useful for product applications.
Background
ONECUT1 is a transcriptional activator. It binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. It is important for liver genes transcription.
References
Lee, Y.S., et al. Biochem. J. 413(3):559-569(2008)
Jiang, X., et al. Oncol. Rep. 19(1):157-163(2008)
Lehner, F., et al. FASEB J. 21(7):1445-1462(2007)
Rausa, F.M. III, et al. J. Biol. Chem. 279(41):43070-43076(2004)
Thomas, H., et al. Nucleic Acids Res. 32 (19), E150 (2004) :
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