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MN1 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MN1 Antibody (Center) AP12722c
    MN1 Antibody (Center) (Cat. #AP12722c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MN1 antibody detected the MN1 protein (arrow).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q10571
Other Accession NP_002421.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 136001 Da
Antigen Region 835-864 aa
Additional Information
Gene ID 4330
Other Names Probable tumor suppressor protein MN1, MN1
Target/Specificity This MN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 835-864 amino acids from the Central region of human MN1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MN1
Function Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable).
Cellular Location Nucleus.
Tissue Location Widely expressed in fetal and adult tissues. Highest expression is observed in fetal brain and skeletal muscle, and adult skeletal muscle.
Research Areas
Citations (0)
citation

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Background

Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis.

References

Liu, T., et al. Leukemia 24(3):601-612(2010)
Kandilci, A., et al. Blood 114(8):1596-1606(2009)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Langer, C., et al. J. Clin. Oncol. 27(19):3198-3204(2009)
Schroeder, T., et al. Leuk. Lymphoma 50(6):1043-1046(2009)

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$ 182.50
$ 70.00
Cat# AP12722c
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