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ABCG4 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ABCG4 Antibody (N-term) AP12723A
    ABCG4 Antibody (N-term) (Cat. #AP12723a) western blot analysis in MDA-MB453,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ABCG4 antibody detected the ABCG4 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9H172
Other Accession NP_001135977.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 71896 Da
Antigen Region 36-65 aa
Additional Information
Gene ID 64137
Other Names ATP-binding cassette sub-family G member 4, ABCG4, WHITE2
Target/Specificity This ABCG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-65 amino acids from the N-terminal region of human ABCG4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsABCG4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCG4 (HGNC:13884)
Synonyms WHITE2
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15240127, PubMed:33141061). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells (PubMed:27228027).
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q91WA9}; Multi-pass membrane protein. Endosome membrane {ECO:0000250|UniProtKB:Q91WA9}; Multi- pass membrane protein
Tissue Location Expressed specifically in the brain and the eye.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
Koshiba, S., et al. Xenobiotica 38 (7-8), 863-888 (2008) :

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$ 365.00
$ 140.00
Cat# AP12723A
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