CT011 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9NWU2 |
Other Accession | Q9D7M1, Q5ZKQ7, Q32L52, NP_060366.1 |
Reactivity | Mouse |
Predicted | Bovine, Chicken |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 26749 Da |
Antigen Region | 44-72 aa |
Gene ID | 54994 |
---|---|
Other Names | Glucose-induced degradation protein 8 homolog, Two hybrid-associated protein 1 with RanBPM, Twa1, GID8, C20orf11 |
Target/Specificity | This CT011 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human CT011. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CT011 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GID8 |
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Function | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046). |
Cellular Location | Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in the absence of Wnt stimulation and in the nucleus in the presence of Wnt stimulation. |
Tissue Location | Up-regulated in colorectal cancer tissues (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Umeda, M., et al. Gene 303, 47-54 (2003) :
Wistow, G., et al. Mol. Vis. 8, 171-184 (2002) :
Deloukas, P., et al. Nature 414(6866):865-871(2001)
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