SCLT1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q96NL6 |
Other Accession | NP_653244.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 80910 Da |
Antigen Region | 577-605 aa |
Gene ID | 132320 |
---|---|
Other Names | Sodium channel and clathrin linker 1, Sodium channel-associated protein 1, SCLT1, SAP1 |
Target/Specificity | This SCLT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 577-605 amino acids from the C-terminal region of human SCLT1. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SCLT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SCLT1 |
---|---|
Synonyms | SAP1 |
Function | Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity). |
Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
SCLT1 acts as a linker protein between the voltage-gated sodium channel Na(v)1.8 (SCN10A; MIM 604427) and clathrin (see CLTC, MIM 118955) (Liu et al., 2005 [PubMed 15797711]).[supplied by OMIM].
References
Liu, C., et al. Mol. Cell. Neurosci. 28(4):636-649(2005)
Tomarev, S.I., et al. Invest. Ophthalmol. Vis. Sci. 44(6):2588-2596(2003)
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