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PAICS Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P22234 |
| Other Accession | P38024, NP_001072992.1, NP_006443.1 |
| Reactivity | Human, Mouse |
| Predicted | Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 47079 Da |
| Antigen Region | 95-123 aa |
| Gene ID | 10606 |
|---|---|
| Other Names | Multifunctional protein ADE2, Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase, Phosphoribosylaminoimidazole carboxylase, AIR carboxylase, AIRC, PAICS, ADE2, AIRC, PAIS |
| Target/Specificity | This PAICS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the N-terminal region of human PAICS. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PAICS Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAICS (HGNC:8587) |
|---|---|
| Function | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Ikeda, M., et al. Biol. Psychiatry 67(3):263-269(2010)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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