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PLCD1 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PLCD1 Antibody (N-term) AP12956A
    PLCD1 Antibody (N-term) (Cat. #AP12956a) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the PLCD1 antibody detected the PLCD1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P51178
Other Accession P10895, NP_001124436.1, NP_006216.2
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 85665 Da
Antigen Region 134-163 aa
Additional Information
Gene ID 5333
Other Names 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase delta-1, Phosphoinositide phospholipase C-delta-1, Phospholipase C-III, PLC-III, Phospholipase C-delta-1, PLC-delta-1, PLCD1
Target/Specificity This PLCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the N-terminal region of human PLCD1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLCD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLCD1 (HGNC:9060)
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:9188725). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (PubMed:7890667, PubMed:9188725).
Tissue Location Strongly expressed in lung, liver and heart. Also expressed at least in pancreas, kidney, skeletal muscle, placenta and brain.
Research Areas
Citations (0)
citation

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Background

Phosphoinositide-specific phospholipase C (PLC) acts as a signal transducer that generates 2 second messengers, diacylglycerol and inositol 1,4,5-trisphosphate, by hydrolyzing inositol phospholipids. PLC comprises a diverse family of enzymes that differ in structure and tissue distribution (Berridge, 1993 [PubMed 8381210]).

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Guo, Y., et al. J. Biol. Chem. 285(32):24999-25008(2010)
Segat, L., et al. Vaccine 28(10):2201-2206(2010)
Godin, C.M., et al. Mol. Pharmacol. 77(3):388-395(2010)

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$ 182.50
$ 70.00
Cat# AP12956A
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