RRP7A Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9Y3A4 |
Other Accession | Q9NSQ0, Q9D1C9, NP_056518.2 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 32334 Da |
Antigen Region | 240-269 aa |
Gene ID | 27341 |
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Other Names | Ribosomal RNA-processing protein 7 homolog A, Gastric cancer antigen Zg14, RRP7A |
Target/Specificity | This RRP7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-269 amino acids from the C-terminal region of human RRP7A. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RRP7A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RRP7A (HGNC:24286) |
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Function | Nucleolar protein that is involved in ribosomal RNA (rRNA) processing (PubMed:33199730). Also plays a role in primary cilia resorption, and cell cycle progression in neurogenesis and neocortex development (PubMed:33199730). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). |
Cellular Location | Nucleus, nucleolus. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
Tissue Location | Expressed in the apical radial glial cells in the developing brain. |
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Provided below are standard protocols that you may find useful for product applications.
References
Line, A., et al. Br. J. Cancer 86(11):1824-1830(2002)
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