SEMA4C Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
---|---|
Primary Accession | Q9C0C4 |
Other Accession | Q64151, NP_060259.4 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 92623 Da |
Antigen Region | 792-821 aa |
Gene ID | 54910 |
---|---|
Other Names | Semaphorin-4C, SEMA4C, KIAA1739, SEMAI |
Target/Specificity | This SEMA4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 792-821 amino acids of human SEMA4C. |
Dilution | WB~~1:4000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SEMA4C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SEMA4C |
---|---|
Synonyms | KIAA1739, SEMAI |
Function | Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. |
Cellular Location | Postsynaptic density membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
References
Wu, H., et al. Eur. J. Cell Biol. 86(6):331-344(2007)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Inagaki, S., et al. J. Biol. Chem. 276(12):9174-9181(2001)
Ohoka, Y., et al. Biochem. Biophys. Res. Commun. 280(1):237-243(2001)
Wang, L.H., et al. J. Biol. Chem. 274(20):14137-14146(1999)
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