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NAT1 Antibody (center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NAT1 Antibody (center) AP13168c
    NAT1 Antibody (center) (Cat. #AP13168c) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the NAT1 antibody detected the NAT1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P18440
Other Accession P11246, P18605, NP_001153645.1, NP_001153642.1, NP_000653.3, NP_001153643.1, NP_001153644.1
Reactivity Human
Predicted Rabbit
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 33899 Da
Antigen Region 102-130 aa
Additional Information
Gene ID 9
Other Names Arylamine N-acetyltransferase 1, Arylamide acetylase 1, Monomorphic arylamine N-acetyltransferase, MNAT, N-acetyltransferase type 1, NAT-1, NAT1, AAC1
Target/Specificity This NAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the Central region of human NAT1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNAT1 Antibody (center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NAT1
Synonyms AAC1
Function Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Cellular Location Cytoplasm.
Research Areas
Citations (0)
citation

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Background

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human geneome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Minchin, R.F., et al. Int. J. Biochem. Cell Biol. 39(11):1999-2005(2007)
Barker, D.F., et al. Pharmacogenet. Genomics 16(7):515-525(2006)
Boukouvala, S., et al. Basic Clin. Pharmacol. Toxicol. 96(5):343-351(2005)

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$ 182.50
$ 70.00
Cat# AP13168c
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