SSR2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | P43308 |
Other Accession | Q5E9E4, NP_003136.1 |
Reactivity | Human |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 20135 Da |
Antigen Region | 154-183 aa |
Gene ID | 6746 |
---|---|
Other Names | Translocon-associated protein subunit beta, TRAP-beta, Signal sequence receptor subunit beta, SSR-beta, SSR2, TRAPB |
Target/Specificity | This SSR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the C-terminal region of human SSR2. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SSR2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SSR2 |
---|---|
Synonyms | TRAPB |
Function | TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Sikorska, M., et al. J. Neurosci. Res. 86(8):1680-1693(2008)
Zhang, H., et al. Nat. Biotechnol. 21(6):660-666(2003)
Wang, L., et al. FEBS Lett. 457(3):316-322(1999)
Dodson, G., et al. Curr. Opin. Struct. Biol. 8(2):189-194(1998)
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