CDH22 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q9UJ99 |
Other Accession | NP_067071.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 89091 Da |
Antigen Region | 411-440 aa |
Gene ID | 64405 |
---|---|
Other Names | Cadherin-22, Pituitary and brain cadherin, PB-cadherin, CDH22, C20orf25 |
Target/Specificity | This CDH22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 411-440 amino acids from the Central region of human CDH22. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CDH22 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CDH22 |
---|---|
Synonyms | C20orf25 |
Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity). |
Cellular Location | Cell membrane; Single-pass type I membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs.
References
Lewis, J.P., et al. Genomics (2010) In press :
Liu, Y., et al. Cancer Biol. Ther. 8(14):1352-1359(2009)
Zhou, J., et al. Tumour Biol. 30(3):130-140(2009)
Bento, J.L., et al. Genomics 92(4):226-234(2008)
Wu, J., et al. J. Endocrinol. 176(3):381-391(2003)
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