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GFRA4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9GZZ7 |
| Other Accession | NP_665705.1, NP_071422.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31670 Da |
| Antigen Region | 156-184 aa |
| Gene ID | 64096 |
|---|---|
| Other Names | GDNF family receptor alpha-4, GDNF receptor alpha-4, GDNFR-alpha-4, GFR-alpha-4, Persephin receptor, GFRA4 |
| Target/Specificity | This GFRA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from the Central region of human GFRA4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GFRA4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GFRA4 |
|---|---|
| Function | Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. |
| Cellular Location | [Isoform GFRalpha4a]: Cell membrane; Lipid- anchor, GPI-anchor [Isoform GFRalpha4c]: Secreted. |
| Tissue Location | Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands |
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
References
Yang, J., et al. FEBS Lett. 569 (1-3), 267-271 (2004) :
Borrego, S., et al. J. Med. Genet. 40 (3), E18 (2003) :
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Zhou, B., et al. Pediatr. Neurol. 25(2):156-161(2001)
Lindahl, M., et al. J. Biol. Chem. 276(12):9344-9351(2001)
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