ELAVL3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q14576 |
Other Accession | Q60900, NP_115657.2, NP_001411.2 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 39547 Da |
Antigen Region | 71-99 aa |
Gene ID | 1995 |
---|---|
Other Names | ELAV-like protein 3, Hu-antigen C, HuC, Paraneoplastic cerebellar degeneration-associated antigen, Paraneoplastic limbic encephalitis antigen 21, ELAVL3, HUC, PLE21 |
Target/Specificity | This ELAVL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-99 amino acids from the N-terminal region of human ELAVL3. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ELAVL3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ELAVL3 |
---|---|
Synonyms | HUC, PLE21 |
Function | RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437). May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity). |
Tissue Location | Brain specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
References
Behrends, U., et al. Int. J. Cancer 100(6):669-677(2002)
Park, S., et al. Mol. Cell. Biol. 20(13):4765-4772(2000)
King, P.H. Nucleic Acids Res. 28 (7), E20 (2000) :
Sakai, K., et al. Biochem. Biophys. Res. Commun. 256(2):263-268(1999)
Van Tine, B.A., et al. Genomics 53(3):296-299(1998)
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