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BEAN Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q3B7T3 |
| Other Accession | NP_001129578.1, NP_001171491.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28626 Da |
| Antigen Region | 45-73 aa |
| Gene ID | 146227 |
|---|---|
| Other Names | Protein BEAN1, Brain-expressed protein associating with Nedd4 homolog, BEAN, BEAN1 |
| Target/Specificity | This BEAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-73 amino acids from the N-terminal region of human BEAN. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BEAN Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BEAN1 |
|---|---|
| Cellular Location | Membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is one of several proteins that interact with NEDD4, a member of a family of ubiquitin-protein ligases. These proteins have PY motifs in common that bind to the WW domains of NEDD4. NEDD4 is developmentally regulated, and is highly expressed in embryonic tissues. Mutations in this gene (i.e., intronic insertions of >100 copies of pentanucleotide repeats including a (TGGAA)n sequence) are associated with spinocerebellar ataxia type 31. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
References
Sato, N., et al. Am. J. Hum. Genet. 85(5):544-557(2009)
Jolliffe, C.N., et al. Biochem. J. 351 PT 3, 557-565 (2000) :
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