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TUBA4A Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P68366 |
| Other Accession | Q5XIF6, P68368, P68367, P81948, NP_005991.1 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Bovine, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49924 Da |
| Antigen Region | 417-446 aa |
| Gene ID | 7277 |
|---|---|
| Other Names | Tubulin alpha-4A chain, Alpha-tubulin 1, Testis-specific alpha-tubulin, Tubulin H2-alpha, Tubulin alpha-1 chain, TUBA4A, TUBA1 |
| Target/Specificity | This TUBA4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 417-446 amino acids from the C-terminal region of human TUBA4A. |
| Dilution | WB~~1:8000 IHC-P~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TUBA4A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TUBA4A |
|---|---|
| Synonyms | TUBA1 |
| Function | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Cellular Location | Cytoplasm, cytoskeleton. |
Provided below are standard protocols that you may find useful for product applications.
Background
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.
References
Houck, S.A., et al. PLoS ONE 5 (7), E11795 (2010) :
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)
Fiore, G., et al. Neurosci. Lett. 394(1):57-62(2006)
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