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CTAG2 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CTAG2 Antibody (Center) AP13767c
    CTAG2 Antibody (Center) (Cat. #AP13767c) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the CTAG2 antibody detected the CTAG2 protein (arrow).
    detail
  • IHC-P - CTAG2 Antibody (Center) AP13767c
    CTAG2 Antibody (Center) (AP13767c)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CTAG2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession O75638
Other Accession NP_758965.1, NP_066274.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 21090 Da
Antigen Region 122-149 aa
Additional Information
Gene ID 30848
Other Names Cancer/testis antigen 2, CT2, Autoimmunogenic cancer/testis antigen NY-ESO-2, Cancer/testis antigen 62, CT62, L antigen family member 1, LAGE-1, CTAG2, ESO2, LAGE1
Target/Specificity This CTAG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-149 amino acids from the Central region of human CTAG2.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCTAG2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTAG2
Synonyms ESO2, LAGE1
Tissue Location Testis and very low level in placenta and in some uterus samples. Observed in 25-50% of tumor samples of melanomas, non- small-cell lung carcinomas, bladder, prostate and head and neck cancers
Research Areas
Citations (0)
citation

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Background

This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID 10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq].

References

Wang, X.Y., et al. Oncol. Rep. 21(3):713-719(2009)
Shao, Y., et al. J. Cancer Res. Clin. Oncol. 134(4):495-502(2008)
Andrade, V.C., et al. Cancer Immun. 8, 2 (2008) :
Kan, T., et al. Oncology 70(1):25-33(2006)
Scanlan, M.J., et al. Immunol. Rev. 188, 22-32 (2002) :

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$ 365.00
$ 140.00
Cat# AP13767c
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