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PCIA1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9BW61 |
| Other Accession | Q5U550, Q9D9Z5, Q7T2A3, Q5ZK14, Q5E9A9, NP_076955.1 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Zebrafish, Mouse, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 11835 Da |
| Antigen Region | 11-40 aa |
| Gene ID | 79016 |
|---|---|
| Other Names | DET1- and DDB1-associated protein 1, Placenta cross-immune reaction antigen 1, PCIA-1, DDA1, C19orf58, PCIA1 |
| Target/Specificity | This PCIA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-40 amino acids from the Central region of human PCIA1. |
| Dilution | WB~~1:300 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PCIA1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DDA1 {ECO:0000303|PubMed:17452440, ECO:0000312|HGNC:HGNC:28360} |
|---|---|
| Function | Functions as a component of numerous distinct DCX (DDB1-CUL4- X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17452440, PubMed:28437394, PubMed:28302793, PubMed:31686031, PubMed:31819272). In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex (PubMed:31686031, PubMed:31819272). |
Provided below are standard protocols that you may find useful for product applications.
Background
PCIA1 may be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.
References
Olma, M.H., et al. J. Cell. Sci. 122 (PT 7), 1035-1044 (2009) :
Pick, E., et al. Mol. Cell. Biol. 27(13):4708-4719(2007)
Li, Z.M., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24(3):279-283(2007)
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