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SENP5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96HI0 |
| Other Accession | Q6NXL6, Q8WP32, NP_689912.2 |
| Reactivity | Human |
| Predicted | Monkey, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 86693 Da |
| Antigen Region | 718-747 aa |
| Gene ID | 205564 |
|---|---|
| Other Names | Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5, SENP5 |
| Target/Specificity | This SENP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-747 amino acids from the C-terminal region of human SENP5. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SENP5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SENP5 |
|---|---|
| Function | Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. |
| Cellular Location | Nucleus, nucleolus |
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Provided below are standard protocols that you may find useful for product applications.
Background
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).
References
Yun, C., et al. J. Cell Biol. 183(4):589-595(2008)
Ding, X., et al. Oncol. Rep. 20(5):1041-1045(2008)
Gong, L., et al. J. Biol. Chem. 281(23):15869-15877(2006)
Di Bacco, A., et al. Mol. Cell. Biol. 26(12):4489-4498(2006)
Yeh, E.T., et al. Gene 248 (1-2), 1-14 (2000) :
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