NR2C1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P13056 |
Other Accession | Q95K90, A0JNE3, NP_001027458.1, NP_001120834.1 |
Reactivity | Human |
Predicted | Bovine, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 67315 Da |
Antigen Region | 516-545 aa |
Gene ID | 7181 |
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Other Names | Nuclear receptor subfamily 2 group C member 1, Orphan nuclear receptor TR2, Testicular receptor 2, NR2C1, TR2 |
Target/Specificity | This NR2C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-545 amino acids from the C-terminal region of human NR2C1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NR2C1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NR2C1 |
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Synonyms | TR2 |
Function | Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Nucleus, PML body. Note=Recruited by HDAC3, after all- trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lin, Y.L., et al. Biochem. Biophys. Res. Commun. 350(2):430-436(2006)
Li, G., et al. Biochem. Biophys. Res. Commun. 310(2):384-390(2003)
Mu, X., et al. Prostate 57(2):129-133(2003)
Franco, P.J., et al. Mol. Endocrinol. 15(8):1318-1328(2001)
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