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BOLL Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N9W6 |
| Other Accession | Q8WP23, NP_149019.1, NP_932074.1 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31301 Da |
| Antigen Region | 23-51 aa |
| Gene ID | 66037 |
|---|---|
| Other Names | Protein boule-like, BOLL, BOULE |
| Target/Specificity | This BOLL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-51 amino acids from the N-terminal region of human BOLL. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BOLL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BOLL |
|---|---|
| Synonyms | BOULE |
| Function | Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity). |
| Cellular Location | Cytoplasm |
| Tissue Location | Testis specific. Not expressed in early embryos, primordial germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis |
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Provided below are standard protocols that you may find useful for product applications.
Background
BOLL belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition.
References
Chen, P., et al. J. Androl. 31(2):163-168(2010)
Kee, K., et al. Nature 462(7270):222-225(2009)
Lin, Y.M., et al. J. Clin. Endocrinol. Metab. 94(7):2650-2657(2009)
Bilguvar, K., et al. Nat. Genet. 40(12):1472-1477(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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