CSPG5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | O95196 |
Other Accession | NP_006565.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 60016 Da |
Antigen Region | 530-559 aa |
Gene ID | 10675 |
---|---|
Other Names | Chondroitin sulfate proteoglycan 5, Acidic leucine-rich EGF-like domain-containing brain protein, Neuroglycan C, CSPG5, CALEB, NGC |
Target/Specificity | This CSPG5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 530-559 amino acids from the C-terminal region of human CSPG5. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CSPG5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CSPG5 |
---|---|
Synonyms | CALEB, NGC |
Function | May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9ERQ6}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9ERQ6} Synaptic cell membrane {ECO:0000250|UniProtKB:Q71M36}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q71M36}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q71M36}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q71M36}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q71M36}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q71M36}. Cell surface {ECO:0000250|UniProtKB:Q71M36}. Secreted. Note=In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi Partially enriched in lipid rafts. {ECO:0000250|UniProtKB:Q71M36, ECO:0000250|UniProtKB:Q9ERQ6} |
Tissue Location | Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Detected in urine (at protein level) (PubMed:37453717). Expressed in brain (at protein level) (PubMed:9950058). |
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Provided below are standard protocols that you may find useful for product applications.
Background
CSPG5 may function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.
References
So, H.C., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (1), 103-113 (2010) :
Ichihara-Tanaka, K., et al. J. Biol. Chem. 281(41):30857-30864(2006)
Aono, S., et al. J. Neurosci. Res. 83(1):110-118(2006)
Kinugasa, Y., et al. Biochem. Biophys. Res. Commun. 321(4):1045-1049(2004)
Hassel, B., et al. J. Biol. Chem. 278(41):40136-40143(2003)
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