CRLF1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O75462 |
Other Accession | Q9JM58, NP_004741.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 46302 Da |
Antigen Region | 255-283 aa |
Gene ID | 9244 |
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Other Names | Cytokine receptor-like factor 1, Cytokine-like factor 1, CLF-1, ZcytoR5, CRLF1 |
Target/Specificity | This CRLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-283 amino acids from the Central region of human CRLF1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CRLF1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CRLF1 |
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Function | In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system. |
Cellular Location | Secreted. |
Tissue Location | Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq].
References
Tsuritani, K., et al. Calcif. Tissue Int. 86(1):47-57(2010)
Crisponi, L., et al. Am. J. Hum. Genet. 80(5):971-981(2007)
Dagoneau, N., et al. Am. J. Hum. Genet. 80(5):966-970(2007)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Heese, K., et al. J. Cell. Biochem. 91(5):1030-1042(2004)
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